| Converse College | Private, For-profit, 4 years or more | Masters | Spartanburg, 29302 |
| Institute of Cosmetic Arts | Private, Non-profit, Less than 2 years | Non-degree granting | Spartanburg, 29306 |
| Sherman College of Straight Chiropractic | Private, For-profit, 4 years or more | First Professional | Spartanburg, 29316 |
| Spartanburg Methodist College | Private, For-profit, 2 to 4 years | Associates | Spartanburg, 29301 |
| Spartanburg Technical College | Public, 2 to 4 years | Associates | Spartanburg, 29303 |
| University of South Carolina-Upstate | Public, 4 years or more | Masters | Spartanburg, 29303 |
| Wofford College | Private, For-profit, 4 years or more | Bachelors | Spartanburg, 29303 |
